Affiliation of Author, Researcher, or Creator
School of Communication
Department
Communication Sciences and Disorders
Author(s)
Dejan Jakimovski, Bianca Weinstock -Guttman, Alex Burnham, Zachary Weinstock, Taylor R Wicks, Murali Ramanathan, Tommaso Sciortino, Mark Ostrem, Christopher Suchan, Michael G Dwyer, Jessica Reilly, Niels Bergsland, Ferdinand Schweser, Cheryl Kennedy, David Young-Hong, Svetlana P Eckert, David Hojnacki, Ralph HB Benedict , Robert Zivadinov
Resource Type
Article
Publication, Publisher or Distributor
Multiple Sclerosis and Related Disorders
Publication Date
7-2024
Brief Description
PwMS recruited from The Boston Home (TBH), a specialized residential facility for severly-affected pwMS and University at Buffalo (UB) MS Center were assessed using EDSS, MS Severity Scale, age-related MSS, Scripps Neurological Rating Scale (SNRS) and Combinatorial Weight-Adjusted Disability Score (CombiWISE). In all scores except SNRS, higher score indicates greater disability. MRI measures of T1, T2-lesion volume (LV), whole brain, gray matter, medulla oblongata and thalamic volumes (WBV, GMV, MOV, TV) and thalamic dysconnectivity were obtained.
Results
Greatest disability differences between the TBH and UB pwMS were in SNRS (24.4 vs 71.9, p < 0.001, Cohen's d = 4.05) and CombiWISE (82.3 vs. 38.9, p < 0.001, Cohen's d= 4.02). In combined analysis of all pwMS, worse SNRS scores were correlated with worse MRI pathology in 8 out of 9 outcomes. EDSS only with 3 measures (GMV, MOV and TV). In severely-affected pwMS, SNRS was associated with T1-LV, T2-LV and WBV (not surviving false discovery rate (FDR) correction for multiple comparisons) whereas EDSS did not.
Conclusion
Granular and dynamic disability measures may bridge the clinico-radiologcal gap present in severely affected pwMS.
Keywords
Multiple sclerosis, Disability scales, Severely disabled MS, Clinico-radiological paradox, EDSS, MSSS, SNRS
Recommended Citation
https://doi.org/10.1016/j.msard.2024.105630.
Preferred Citation Style
APA
Peer Reviewed
1
License Agreement
1